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The addition of a CDK4/6i to endocrine therapy improves response rates, progression-free and overall survival with manageable toxicity. 2 Li J. Huo X. Zhao F. et al. Association of cyclin-dependent kinases 4 and 6 inhibitors with survival in patients with hormone receptor-positive metastatic breast cancer: a systematic review and meta-analysis. JAMA Netw Open.
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