ADDRESSING THE LOSS OF DESIRE The loss of sexual desire, or the lack of motivation to engage in sexual activity, occurs commonly after treatment and is a common source of noteworthy distress. It can be primary or secondary, and distinguishing the two is important. For many women, loss of desire can be the result of many issues, including negative body image, changes in the sense of touch, and discomfort or pain with attempted penetrative activities, termed genitopelvic pain disorder.