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Abstract Retinal ganglion cell (RGC) degeneration and the limited regenerative capacity of mammalian central nervous system axons result in irreversible vision loss in optic neuropathies. Identifying intrinsic regulators that promote both neuroprotection and axon regeneration is critical for developing effective therapies. This study identified POU domain class 2 transcription factor 2 (Pou2f2) as a previously unrecognized regulator involved in RGC biology.
Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, converts glucose to sorbitol using NADPH and becomes markedly overactive under hyperglycemic conditions. Its widespread expression in ocular tissues links AR to numerous eye disorders through sorbitol accumulation, microglial activation, NADPH depletion, oxidative stress, and increased formation of advanced glycation end products.
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