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Abstract Although depression significantly impacts fitness, some hypotheses suggest that it may offer a survival benefit. However, there has been limited systematic investigation into the selection pressures acting on genes associated with depression at the genomic level.
The authors have declared no competing interest. This study was supported by the National Key R&D Program of China (2022YFC2704200), the National Natural Science Foundation of China (81903037), the Natural Science Foundation of Guangdong Province, China (2020A1515011281), and the Nature Science Foundation of China (No.81772769). Part of the data computation was supported by National Supercomputer Center in Guangzhou, China.
Abstract Cancer is one of the most threatening diseases to humans. Understanding the evolution of cancer genes is helpful for therapy management. However, systematic investigation of the evolution of cancer driver genes is sparse.
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