Rationale, aims, and objectives The psychometrics of the Short‐Form 36 Health Survey version 2 (SF‐36v2) in female breast cancer patients remains unknown. This study aimed to test the reliability, validity, and sensitivity of the Chinese SF‐36v2 in women with breast cancer. Methods The sample included 326 eligible participants. The reliability and the item convergent and discriminant validity were estimated using Cronbach α (≥0.70) and the multi‐trait multi‐item matrix analysis, respectively.