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1 Introduction Auricular morphological deformity (AMD), encompassing conditions such as lop ear, prominent ear, cup ear, cryptotia, and Stahl's ear, is more prevalent than structural malformations. These deformities not only disrupt the natural aesthetic harmony of the auricle but may also exert varying degrees of negative psychological impact on affected children. While some AMD may self-correct [1], most require early intervention.
Back to Journals » OncoTargets and Therapy » Volume 19 Authors Cui L, Ran C, Liu S, Xu C, Zhang L, Peng Y, Feng Y, Li X Received 2 June 2026 Accepted for publication 6 October 2026 Published 13 October 2026 Volume 2026:19 622880 DOI https://doi.org/10.2147/OTT.S622880 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Prof.
Abstract UL-16 binding protein 1 (ULBP1), a ligand for the NK cell-stimulatory receptor NKG2D, is expressed as a cell-surface protein on malignant cells. While accumulating evidence links ULBP1 to cancer progression, its pan-cancer immunological and clinical significance remains underexplored. Through systematic bioinformatics analyses of 33 malignancies, we uncovered that widespread ULBP1 dysregulation across cancers was associated with advanced tumor staging and patient survival.
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