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Articles by Larry Hawk
Nicotine E-Cigarettes for Cigarette Smoking Cessation : Recommendations to US-Based Clinicians
Nicotine E-Cigarettes for Cigarette Smoking Cessation: Recommendations to US-Based Clinicians Abstract Importance Cigarette smoking, maintained predominantly by nicotine dependence, is a long-term and relapsing behavior that continues to be a leading cause of preventable death and disease worldwide. E-cigarettes with nicotine are less harmful than cigarettes and have been shown to be more effective for smoking cessation than US Food and Drug Administration–approved nicotine replacement therapies.
Genetic Prediction of Smoking Cessation Medication Side Effects: A Genome‐Wide Investigation of Abnormal Dreams on Varenicline
WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Varenicline, the most efficacious smoking cessation aid, produces sleep disturbances including abnormal dreams. Genetic factors influence numerous smoking behaviors including pharmacotherapy-supported cessation outcomes and medication side effects. However, the role of genetics in varenicline-associated abnormal dreams is unknown. WHAT QUESTION DID THIS STUDY ADDRESS?
Health Equity and Decentralized Trials
The COVID-19 pandemic resulted in unprecedented challenges to clinical research activities, including more than 1100 trials being stopped per month during peak periods of global spread.1 Even though Pfizer conducted the first fully decentralized randomized clinical trial of an investigational drug in 2011,2 the COVID-19 pandemic accelerated a methodological shift from clinical trials being conducted entirely within traditional medical research institutions toward making trials available to...
Outdated cap on NIH research grant budgets
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Effect of Extending the Duration of Prequit Treatment With Varenicline on Smoking Abstinence
[Skip to Navigation] Visual Abstract. RCT: Effect of Extending the Duration of Prequit Treatment With Varenicline on Smoking Abstinence Figure 1. Flow Diagram of Trial Recruitment and Eligibility Evaluation, Intervention Randomization, Treatment and Follow-up, and Analysis EMA indicates ecological momentary assessment; ITT, intention to treat. Figure 2.
How do stimulant treatments for ADHD work? Evidence for mediation by improved cognition
Stimulant medications such as methylphenidate (MPH) are the frontline treatment for Attention‐Deficit/Hyperactivity Disorder (ADHD). Despite their well‐documented efficacy, the mechanisms by which stimulants improve clinical outcomes are not clear. The current study evaluated whether MPH effects on classroom behavior were mediated by improved cognitive functioning.
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