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Articles by Lars Bergmann
Update der S3-Leitlinie Sepsis 2025 – was ist neu?
The recently revised German Sepsis Guideline 2025 reflects an increasing integration of personalised therapy principles. This trend is observed in key recommendations relating to early recognition, anti-infective therapy, hemodynamic support, and organ-protective strategies. Early detection should be performed using validated screening instruments.
Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie / Abstract
Mit der Veröffentlichung der aktualisierten S1-Leitlinie zum Atemwegsmanagement im Jahr 2023 hat die Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI) einen Meilenstein gesetzt, der die Fortschritte beim Atemwegsmanagement evidenzbasiert zusammenfasst und klare Handlungsempfehlungen formuliert. Diese Überarbeitung ist nicht nur ein theoretisches Update, sondern auch ein praktischer Wegweiser für den klinischen Alltag.
Foslevodopa/foscarbidopa (LDp/CDp) in advanced Parkinson’s Disease (aPD): demonstration of savings from a societal perspective in the UK
Abstract Aims In advanced Parkinson’s disease (aPD), adequate 24-hour control of OFF-time may not be achievable using oral/transdermal therapies. Clinical trials of foslevodopa/foscarbidopa (LDp/CDP) demonstrate meaningful reductions in OFF-time and OFF-related sleep disturbance in aPD. Previous analyses have only considered direct medical costs: this analysis considers a broader societal perspective (direct non-medical costs, informal care, loss of earnings, productivity and tax).
Effect of Intraoperative Handovers of Anesthesia Care on Mortality, Readmission, or Postoperative Complications
Key Points Question Among adults undergoing extended surgical procedures, what is the effect of an intraoperative handover of anesthesia care on clinical outcomes? Findings In this randomized clinical trial that included 1772 patients, the composite primary outcome of mortality, readmission, or serious postoperative complications within 30 days did not differ significantly among participants randomized to receive handover of anesthesia care vs no handover of care (30% vs 33%, respectively).
Age/disease duration influence on activities of daily living and quality of life after levodopa-carbidopa intestinal gel in Parkinson's disease
This study was supported by AbbVie Inc., North Chicago, IL, USA. A Antonini was a study investigator and has received compensation for consultancy and speaker-related activities from UCG, Boston Scientific, Boehringer Ingelheim, AbbVie and Zambon. He has received research support from Mundipharma. WZ Robieson and L Bergmann are employees of AbbVie and may hold AbbVie stock and/or stock options. A Yegin was an employee of AbbVie at the time of the study; she is currently employed at Biogen.
Age/disease duration influence on activities of daily living and quality of life after levodopa-carbidopa intestinal gel in Parkinson's disease
Aim: To determine if age and Parkinson's disease duration at therapy initiation influence the efficacy of levodopa-carbidopa intestinal gel (LCIG) on quality of life and activities of daily living. Patients & methods: This post hoc analysis assessed subgroups of patients stratified by baseline age, disease duration, hours/day of ‘off’ time and levodopa equivalent dose. Patients’ data were collected from the GLORIA study, a 24-month observational registry evaluating long-term effectiveness of LCIG.
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