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Abstract Streptococcus suis is a major cause of meningitis, septicemia, and arthritis in swine, and its control is complicated by antimicrobial resistance and the absence of broadly protective vaccines. We evaluated a data-driven, integrated control program in a 3-year prospective, single-site quality-improvement study using an interrupted time-series design in a PRRSV-free, 1,000-sow herd comprising approximately 126,000 liveborn piglets.
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