Key Points Question Can basal cell carcinomas (BCCs) be identified at a subclinical stage with systematic screening of the face using artificial intelligence–assisted line-field confocal optical coherence tomography? Findings In this cross-sectional feasibility study of 150 patients at increased risk for BCC, histologically confirmed subclinical BCCs were identified in 14 patients (9.3%) with a positive predictive value of 83.3%.