Genetic Diversity and Evolution Samuel Long, Christine M. Fennessey, Laura Newman, Carolyn Reid, Sean P. O’Brien, Yuan Li, Gregory Q. Del Prete, Jeffrey D. Lifson, Robert J. Gorelick, Brandon F. Keele Frank Kirchhoff, Editor DOI: 10.1128/JVI.01308-19 ABSTRACT The major obstacle to more-definitive treatment for HIV infection is the early establishment of virus that persists despite long-term combination antiretroviral therapy (cART) and can cause recrudescent viremia if cART is interrupted.