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Articles by Le Hir
Unexpected regulatory functions of cyprinid Viperin on inflammation and metabolism - BMC Genomics
The Epithelioma papulosum cyprini (EPC) cell line (ATCC CRL-2872, Pimephales promelas), was grown in Leibovitz’s L-15 medium (Gibco) supplemented with 10% fetal bovine serum (FBS, Eurobio) and penicillin (100 U/mL)-streptomycin (100 μg/mL) (BioValley). The EPC-EC cell line (described below) and its derivatives were grown in L-15 medium supplemented with 10% FBS, penicillin (100 U/mL)-streptomycin (100 μg/mL), 500 μg/mL G418 (Invivogen), 30 μg/mL hygromycin B Gold (Invivogen).
Yellow fever vaccine-associated neurologic and viscerotropic disease: a 10-year case series of the French National Reference Center for arboviruses with clinical and immunological insights
Immunization against the Yellow fever virus (YFV) with the 17D live-attenuated vaccine is the most effective way to prevent the disease. However, unexpected severe adverse events can occur. They consist in a neurological disease (YEL-AND), a viscerotropic disease (YEL-AVD), or anaphylaxis. In this article, we describe the epidemiology, clinical and biological features of YEL-AND and YEL-AVD cases reported to the French National Reference Center for Arboviruses (NRCA) in the past 10 years.
Antisense pre-treatment increases gene therapy efficacy in dystrophic muscles
Peccate, C; Mollard, A; Le Hir, M; Julien, L; McClorey, G; Jarmin, S; Le Heron, A; ... Lorain, S; + view all Peccate, C; Mollard, A; Le Hir, M; Julien, L; McClorey, G; Jarmin, S; Le Heron, A; Dickson, G; Benkhelifa-Ziyyat, S; Piétri-Rouxel, F; Wood, MJ; Voit, T; Lorain, S; - view fewer (2016) Antisense pre-treatment increases gene therapy efficacy in dystrophic muscles. Human Molecular Genetics , 25 (16) pp. 3555-3563. 10.1093/hmg/ddw201.
Cellular plasticity in kidney injury and repair
Abstract Terminally differentiated cells can be reprogrammed to pluripotency or directly to another differentiated cell type in vitro, a capacity termed cellular plasticity. Plasticity is not limited to in vitro manipulations but rather represents an important aspect of the regenerative response to injury in organs.
T helper type 17 cells in immune-mediated glomerular disease
Abstract CD4+ T cells are important drivers of tissue damage in immune-mediated renal diseases, such as anti-glomerular basement membrane glomerulonephritis, anti-neutrophil cytoplasmic antibody-associated glomerulonephritis, and lupus nephritis. The discovery of a distinct, IL-17-producing CD4+ T-cell lineage termed T helper type 17 (TH17) cells has markedly advanced current understanding of the pathogenic mechanisms of organ-specific immunity and the pathways that lead to target organ damage.
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