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Lene Maria

As seen in: American Journal of Epidemiology
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Articles by Lene Maria

Prenatal exposure to benzodiazepine and z-hypnotics and fifth-grade scholastic skills - emulating target trials using data from the Norwegian Mother, Father and Child Cohort Study | American Journal of Epidemiology | Oxford Academic

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By Jon Michael, Lene Maria
| American Journal of Epidemiology Verified
Evidence is limited regarding the effect of prenatal benzodiazepine and z-hypnotic exposure and long-term neurodevelopment in childhood. The objective of this study was to investigate the effects of initiating benzodiazepine or z-hypnotic treatment in early, mid and late pregnancy on fifth-grade numeracy and literacy scholastic skills in children, by emulating three target trials. The trials are identical except for the timing of enrollment and the number of eligible individuals.
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Prenatal exposure to benzodiazepine and z-hypnotics and fifth-grade scholastic skills-emulating target trials using data from the Norwegian Mother, Father and Child Cohort Study | American Journal of Epidemiology | Oxford Academic

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By Lene Maria, Jon Michael
| American Journal of Epidemiology Verified
Benzodiazepines and z-hypnotics are drugs mainly prescribed for the treatment of anxiety and insomnia.1 Up to 15% experience anxiety disorders during pregnancy, often comorbid with depression.2,3 The global prevalence of prescribed benzodiazepines and z-hypnotics during pregnancy is estimated at 1.9%.4 Maternal benzodiazepine or z-hypnotic use may have the potential to influence fetal neurodevelopment,5,6 but studies on child neurodevelopment after prenatal exposure to benzodiazepines and/or...
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