Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Leonie Bole
Sodium mediated deprotonative borylation of arenes using sterically demanding B(CH2SiMe3)3: unlocking polybasic behaviour and competing lateral borane sodiation
Sodium mediated deprotonative borylation of arenes using sterically demanding B(CH2SiMe3)3: unlocking polybasic behaviour and competing lateral borane sodiation† Andreu Tortajada, a Leonie J. Bole,‡a Manting Mu,‡b Martin Stanford, a Marconi N. Peñas-Defrutos, bc Max García-Melchor *b and Eva Hevia *a Abstract The deprotonative metalation of organic molecules has become a convenient route to prepare functionalised aromatic substrates.
Exploiting Coordination Effects for the Regioselective Zincation of Diazines Using TMPZnX⋅LiX (X=Cl, Br)
Introduction N-heterocycles are among the most valuable synthetic scaffolds for pharmaceutical and agrochemical research.1 Their general functionalization has been thoroughly studied2 and various cross-couplings3 or metalations of these N-heterocycles have been reported for such purpose.4 A powerful tool for the preparation of N-heteroaryl organometallics is the directed C−H metalation using sterically hindered, non-nucleophilic metallic amide bases.5 Zinc and magnesium derived TMP-bases...
Progressing the Frustrated Lewis Pair Abilities of N-Heterocyclic Carbene/GaR3 Combinations for Catalytic Hydroboration of Aldehydes and Ketones
Exploiting the steric incompatibility of the tris(alkyl)gallium GaR3 (R = CH2SiMe3) and the bulky N-heterocyclic carbene (NHC) 1,3-bis(tert-butyl)imidazol-2-ylidene (ItBu), here we report the B–H bond activation of pinacolborane (HBPin), which has led to the isolation and structural authentication of a novel ion pair, [{ItBu-BPin}+{GaR3(μ-H)GaR3}−] (2). Contrastingly, neither ItBu or GaR3 was able to react with HBPin under the conditions of this study.
Untangling the Complexity of Mixed Lithium/Magnesium Alkyl/Alkoxy Combinations Utilised in Bromine/Magnesium Exchange Reactions
Communication In memory of Victor Snieckus PDF ShareShare Abstract While it is known that the addition of Group 1 alkoxides to s‐block organometallics can have an activating effect on reactivity, the exact nature of this effect is not that well understood. Here we describe the activation of sBu2Mg towards substituted bromoarenes by adding one equivalent of LiOR (R=2‐ethylhexyl), where unusually both sBu groups can undergo efficient Br/Mg exchange.
Regioselective Bromine/Magnesium Exchange for the Selective Functionalization of Polyhalogenated Arenes and Heterocycles
Abstract Using the bimetallic combination sBu2Mg⋅2 LiOR (R=2‐ethylhexyl) in toluene enables efficient and regioselective Br/Mg exchanges with various dibromo‐arenes and ‐heteroarenes under mild reaction conditions and provides bromo‐substituted magnesium reagents. Assessing the role of Lewis donor additives in these reactions revealed that N,N,N′,N′′,N′′‐pentamethyldiethylenetriamine (PMDTA) finely tunes the regioselectivity of the Br/Mg exchange on dibromo‐pyridines and quinolines.
Ambient Moisture Accelerates Hydroamination Reactions of Vinylarenes with Alkali‐Metal Amides under Air
Communication Dr. Joaquín García‐Álvarez Corresponding Author E-mail address: garciajoaquin@uniovi.es Laboratorio de Compuestos Organometálicos y Catálisis (Unidad Asociada al CSIC), Departamento de Química Orgánica e Inorgánica (IUQOEM), Centro de Innovación en Química Avanzada (ORFEO-CINQA), Facultad de Química, Universidad de Oviedo, 33071 Oviedo, Spain Search for more papers by this author Prof.
Ultrafast amidation of esters using lithium amides under aerobic ambient temperature conditions in sustainable solvents
Ultrafast amidation of esters using lithium amides under aerobic ambient temperature conditions in sustainable solvents†‡ Michael Fairley,a Leonie J. Bole,b Florian F. Mulks, ab Laura Main,a Alan R. Kennedy, a Charles T.
Magnesium-Mediated Arylation of Amines via C-F Bond Activation of Fluoroarenes
Magnesium-Mediated Arylation of Amines via C-F Bond Activation of Fluoroarenes A series of new Mg(II) amides featuring a bulky β-diketiminate backstop ligand, has been synthesised. These complexes are demonstrated to be excellent sources of nucleophilic amides that can participate in rapid C-F activation of several fluoroarenes at room temperature or using microwave assistance, leading to the installment of synthetically important C-N bonds via nucleophilic substitution.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Leonie
Contact Leonie, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack