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Leonie Menghesha

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Articles by Leonie Menghesha

Real-world evaluation of belumosudil for chronic ocular graft-versus-host-disease: Efficacy and outcomes

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By Leonie Menghesha, Tim Richardson, Jana Knuever, Udo Holtick, Christof Scheid, Michael Stern, Philipp Steven
| Nature Verified
Introduction Graft-versus-host disease (GVHD) affects up to 50% of patients after allogeneic hematopoietic stem cell transplantation (aHCT) [1,2,3]. Chronic ocular GVHD (oGVHD) is particularly debilitating, characterized by severe ocular surface disease, inflammation and fibrosis of lacrimal gland, cornea and conjunctiva. Current treatment options for chronic oGVHD are limited, relying on topical therapies, which may not provide significant improvement in advanced cases.
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The effect of posttransplant cyclophosphamide on ocular graft-versus-host disease - Bone Marrow Transplantation

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By Volkan Tahmaz, Leonie Menghesha
| Nature Verified
Introduction Recently, it was recommended that a 3-drug combination of post-transplant cyclophosphamide (PT-Cy), tacrolimus (Tac) and mycophenolate mofetil should be used not only for mismatched transplants but also for closely matched donors. Regarding PT-Cy, it has been shown that a higher 1-year graft-versus-host disease (GVHD)-free and relapse-free survival was achieved compared to standard GVHD prophylaxis with an exclusive calcineurin inhibitor such as Tac and methotrexate [1].
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