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Articles by Liam Bartie
Rapid directed evolution guided by protein language models and epistatic interactions
Abstract Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation stacking, whereas machine learning methods require extensive datasets or multiple experimental rounds and are bottlenecked by costly, length-limited gene synthesis. We present MULTI-evolve, a rapid evolution framework that systematically engineers multimutants.
Site-specific DNA insertion into the human genome with engineered recombinases - Nature Biotechnology
Megabase-scale human genome rearrangement with programmable bridge recombinases
Abstract Bridge recombinases are naturally occurring RNA-guided DNA recombinases that we previously demonstrated can programmably insert, excise, and invert DNA in vitro and in Escherichia coli. In this study, we report the discovery and engineering of the bridge recombinase ortholog ISCro4 for universal rearrangements of the human genome. We defined strategies for the optimal application of bridge systems, leveraging mechanistic insights to improve their targeting specificity.
Megabase-scale human genome rearrangement with programmable bridge recombinases
P.D.H. acknowledges outside interest as a co-founder of Stylus Medicine, Terrain Biosciences, and Monet AI, serves on the board of directors at Stylus Medicine, is a board observer at EvolutionaryScale and Terrain Biosciences, a scientific advisory board member at Arbor Biosciences and Veda Bio, and an advisor to NFDG, Varda Space, and Vial Health. M.G.D. acknowledge outside interest in Stylus Medicine. D.K. acknowledges outside interest in Shape Therapeutics.
Sequence modeling and design from molecular to genome scale with Evo
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2 hours ago Here’s a straightforward list, in no certain order, of Mac apps that I’m currently using. Rocket for easy emoji access• Rocket Typist for expanding text snippets• Just Press Record for accessing recordings from iPhone on the Mac• Audio Hijack for recording podcast appearances and recording live …
By Eric Nguyen, Michael Poli, Matthew Durrant, Brian Kang, Dhruva Katrekar, Liam Bartie, Armin Thomas, Samuel King, Garyk Brixi, Jeremy Sullivan, Madelena Ng, Ashley Lewis, Stefano Ermon, Stephen A. Baccus, Tina Hernandez-Boussard, Christopher Ré, Patrick D. Hsu, Brian L. Hie, Aaron Lou, David K. Li Verified
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Site-specific DNA insertion into the human genome with engineered recombinases
Abstract Technologies for precisely inserting large DNA sequences into the genome are critical for diverse research and therapeutic applications. Large serine recombinases (LSRs) can mediate direct, site-specific genomic integration of multi-kilobase DNA sequences without a pre-installed landing pad, but current approaches suffer from low insertion rates and high off-target activity.
Dealing with Holiday Debt
Money Mentors provides practical tips and free supports for dealing with holiday debt, including credit card balances. For many people, the most wonderful time of the year also ends up being the most expensive. The joy of the holiday season can quickly become overshadowed by the stress of overspending and the looming prospect of an overwhelming credit card balance. There is no quick and easy way to deal with holiday debt.
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