Abstract Immune dysregulation is increasingly recognized as a critical contributor to Alzheimer’s disease (AD), but the specific immune cell contexts and regulatory genes underlying genetic susceptibility remain incompletely understood. Here, we integrated immune cell-specific cis-expression quantitative trait loci (cis-eQTL) from the OneK1K resource with AD genome-wide association study data using two-sample Mendelian randomization (MR), Bayesian colocalization, and independent DICE replication.
