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PURPOSE Men with locally advanced prostate cancer who undergo radical prostatectomy (RP) often develop recurrence and require post-operative radiotherapy. We aimed to determine the safety of neoadjuvant stereotactic body radiotherapy (SBRT) prior to RP in this population. PATIENTS AND METHODS A single institution phase I trial (NCTXXXX) of men with high-risk or node positive prostate cancer enrolled between 3/2017-10/2017.
Background Refractory epigastric/midback pain is associated with locally advanced abdominal malignancies, especially pancreatic cancer. The pain is caused by tumor infiltration of the celiac plexus, a nerve network attached to the abdominal aorta. Contemporary palliative approaches are often inadequate. We hypothesized that ablative radiation targeted to the celiac plexus would alleviate this pain.
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