ABCC6 ATP Binding Cassette Subfamily C Member 6 ALP alkaline phosphatase ATP adenosine triphosphate DKD diabetic kidney disease DM diabetes mellitus ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 GACI generalized arterial calcification of infancy PPi inorganic pyrophosphate PXE pseudoxanthoma elasticum STZ streptozotocin T1D type 1 diabetes T2D type 2 diabetes TNAP tissue nonspecific alkaline phosphatase About 10% of the population has diabetes mellitus (DM), and the prevalence of...