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Linchen Wang

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Articles by Linchen Wang

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

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By Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang
| Wiley Online Library Verified
1 Introduction Ubiquitylation is a complex tripartite enzymatic process involving the ubiquitin activating enzyme (E1), the ubiquitin conjugating enzyme (E2), and the ubiquitin ligase (E3), which collectively catalyzes the attachment of the ubiquitin to a substrate protein.
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Cellular Composition and 5hmC Signature Predict the Treatment Response of AML Patients to Azacitidine Combined with Chemotherapy

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By Guanghao Liang, Qiancheng You, Kirk E. Cahill, Linchen Wang
| Wiley Online Library Verified
AZA Treatment Induced Dose-Dependent 5hmC Changes which were Prognostic AZA treatment is known to affect the genome-wide distribution of DNA 5mC and 5hmC modifications, which have been widely used for the diagnosis and prognosis of various types of cancer.[13] To understand the epigenetic modulation effect of AZA treatment, we characterized genome-wide 5hmC profiles for 120 BM and/or PB samples obtained from 40 patients at Day 0 and/or Day 5 through Nano-hmC-Seal.[26] There were only 19...
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