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Articles by Lingeng Lu
Interplay of gut microbiota, immune cells and natural products in reshaping cancer immunotherapy
Abstract Recent advances have underscored the gut microbiota as an essential orchestrator of host responses to cancer immunotherapy. Gut microbiota and their metabolites play a vital role in modulating host immune responses.
Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns
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Abstract Tobacco use, alcohol consumption, and infection with human papilloma virus (HPV) are well-established risk factors for head and neck squamous cell carcinomas (HNSCC). However, the incidence of oral cancer, particularly in the mobile tongue, has been rising in non-smoker/non-drinker and HPV-negative patients, suggesting the emergence of a new clinical entity.
By Sophie Deneuve, Béatrice Fervers, Julia S. Bruno, Emma Bach, Sergey Senkin, Gabrielle Goldman-Levy, Israa A. Laklouk, Rong Hu, Liacine Bouaoun, Olivia Perol, Berenice Chavanel, Lingeng Lu, Taja Lozar, Tarik Gheit, Paul Lambert, Jiri Zavadil, François Virard, Christine Carreira, Isabelle Coste, Toufic Renno
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Nature
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Correction: Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study | BMC Cancer | Full Text
Correction: Randomized trial of physical activity on quality of life and lung cancer biomarkers in patients with advanced stage lung cancer: a pilot study Correction Open access Published: 15 November 2024 BMC Cancer volume 24, Article number: 1409 (2024) Cite this article The Original Article was published on 01 April 2021 Correction: BMC Cancer 21, 352 (2021) Following publication of the original article [1], the authors report an error.
Asparagine synthetase and G‐protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interests. Supporting Information Filename Description ijc35104-sup-0001-Supinfo.pdfPDF document, 35.7 MB DATA S1: Supporting Information. REFERENCES 1, , . Metabolism and colorectal cancer. Annu Rev Pathol. 2023; 18: 467-492. 2. Nutrition needs of mammalian cells in tissue culture. Science. 1955; 122: 501-514. 3, . Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci. 2010; 35: 427-433. 4, , , et al.
Sensitizing the Efficiency of ICIs by Neoantigen mRNA Vaccines for HCC Treatment
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Potential of Dietary HDAC2i in Breast Cancer Patients Receiving PD-1/PD-L1 Inhibitors
1. Introduction Breast cancer is one of the most common malignancies in women worldwide, which can occur in both men and women, and ranks as the second cancer-related cause of death worldwide [1,2]. Its development has been reported to be significantly associated with dietary habits (such as alcohol consumption, high intake of total fat, and low consumption of dietary fiber, etc.) [3].
Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids
Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer
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Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer
This is a preprint. It has not yet been peer reviewed by a journal. The National Library of Medicine is running a pilot to include preprints that result from research funded by NIH in PMC and PubMed. bioRxiv. Display options Format doi: 10.1101/2023.05.05.539577. Preprint PMID: 37205388 PMCID: PMC10187315 DOI: 10.1101/2023.05.05.539577 Item in Clipboard Display options Abstract The nutrient status of the tumor microenvironment has major impacts on cell growth.
MicroRNAs with Multiple Targets of Immune Checkpoints, as a Potential Sensitizer for Immune Checkpoint Inhibitors in Breast Cancer Treatment
Abstract : Simple Summary Based on the latest research progresses, application of immune checkpoint inhibitors (ICIs) has shown promise in treating breast cancer. Moreover, novel ICIs based combined therapy has been sought to further enhance the curative effect.
Efficacy, Safety, and Challenges of CAR T-Cells in the Treatment of Solid Tumors
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Breast Cancer Patients: Who Would Benefit from Neoadjuvant Chemotherapies?
Open AccessReview by Liqin Yao 1, Gang Jia 2, Lingeng Lu 3,4,5 and Wenxue Ma 6,* 1 Department of Breast and Thyroid Surgery, The First Affiliated Hospital, School of Medicine, Huzhou University, Huzhou 313000, China 2 Department of Medical Oncology, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou 450003, China 3 Department of Chronic Disease Epidemiology, School of Medicine, Yale School of Public Health, New Haven, CT 06520, USA 4 Yale Cancer Center,...
Oral Cyanobacteria and Hepatocellular Carcinoma
Research Articles Brenda Y. Hernandez, Xuemei Zhu, Harvey A. Risch, Lingeng Lu, Xiaomei Ma, Melinda L. Irwin, Joseph K. Lim, Tamar H. Taddei, Karen S. Pawlish, Antoinette M. Stroup, Robert Brown, Zhanwei Wang, Linda L. Wong and Herbert Yu DOI: 10.1158/1055-9965.EPI-21-0804 Published January 2022 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below.
Oral Cyanobacteria and hepatocellular carcinoma
Research Article Brenda Y Hernandez, Xuemei Zhu, Harvey A Risch, Lingeng Lu, Xiaomei Ma, Melinda L Irwin, Joseph K. Lim, Tamar H Taddei, Karen S Pawlish, Antoinette M Stroup, Robert Brown, Zhanwei Wang, Linda L Wong and Herbert Yu DOI: 10.1158/1055-9965.EPI-21-0804 Abstract Background: Gut microbial alterations have been linked to chronic liver disease and hepatocellular carcinoma (HCC). The role of the oral microbiome in liver cancer development has not been widely investigated.
Artificial human antigen presenting cells are superior to dendritic cells at inducing cytotoxic T cell responses
Peptide recognition through the MHC class I molecule by cytotoxic T lymphocytes (CTLs) leads to the killing of cancer cells. A potential challenge for T-cell immunotherapy is that dendritic cells (DCs) are exposed to the MHC class I-peptide complex for an insufficient amount of time.
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