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Abstract Small cell lung cancer (SCLC) is initially sensitive to platinum chemotherapy, yet resistant disease frequently develops with altered neuroendocrine (NE) identity. The mechanisms linking these cell states to treatment tolerance remain incompletely understood. Here, we integrate chemoresistant cell models with patient bulk multiomics, single-cell and spatial transcriptomic data to investigate the mechanosensitive channel PIEZO1.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
