Abstract Objective: This study aimed to systematically assess perioperative clinical safety, medium-term weight loss outcomes, multidisciplinary management challenges, and the clinical applicability of laparoscopic sleeve gastrectomy (LSG) in adults with Prader-Willi syndrome (PWS) and super-morbid obesity (body mass index [BMI] ≥ 50 kg/m²), with the objective of identifying appropriate candidates for surgical intervention and establishing standardized perioperative management strategies.
