Aberrant activation of Wnt/?-catenin signalling contributes significantly to the development of human colorectal cancers and ?-catenin is the key signalling molecule transducing canonical Wnt/?-catenin signalling. Therefore, ?-catenin is a promising therapeutic target for cancer treatment. This study demonstrates that the oncogenic IKK? kinase phosphorylates ?-catenin to restrain its hyper activation, therefore promoting colorectal cancer (CRC) cell proliferation. IKK?