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Zanxian Xia

As seen in: Color Research & Application
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Articles

Hyper activation of β-catenin signalling induced by IKKε inhibition thwarts colorectal cancer cell proliferation

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By Jie Chen, Jun Zhao, Xuan Chen, Katie Lee, Zanxian Xia, Jian Peng, Chengming Ding, Zeming Jia, Yaoting Zhang, Yuzheng Zhou, Chaoying Wei, Jiantai He
| Color Research & Application Verified
Aberrant activation of Wnt/?-catenin signalling contributes significantly to the development of human colorectal cancers and ?-catenin is the key signalling molecule transducing canonical Wnt/?-catenin signalling. Therefore, ?-catenin is a promising therapeutic target for cancer treatment. This study demonstrates that the oncogenic IKK? kinase phosphorylates ?-catenin to restrain its hyper activation, therefore promoting colorectal cancer (CRC) cell proliferation. IKK?
Open in Who Shared Issue with article?
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By Jun Zhao, Yi Zeng, Simin Xu, Jie Chen, Guobo Shen, Weiming Yuan, Jian Peng, Wenqing Xu, Chao Zhang, Caiqun Yu, David Knipe, Zanxian Xia, Pinghui Feng
| secure.jbs.elsevierhealth.com
Open in Who Shared Issue with article?
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