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Articles by Linus Backert
Pitfalls in HLA ligandomics - How to catch a li(e)gand
Highlights • Best practices to identify true HLA ligands as targets for cancer immunotherapies • Quality control in mass-spectrometry to improve neoantigen/crypto-target discovery • Computational methods to assess fragment contamination in immunopeptidomics • Experimental methods for LC system suitability testing and HT sequence verification Abstract Knowledge about the peptide repertoire presented by human leukocyte antigens (HLA) holds the key to unlock target-specific cancer...
Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation
Tumor Biology and Immunology Mapping the HLA Ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation Markus W. Löffler, Daniel J. Kowalewski, Linus Backert, Jörg Bernhardt, Patrick Adam, Heiko Schuster, Florian Dengler, Daniel Backes, Hans-Georg Kopp, Stefan Beckert, Silvia Wagner, Ingmar Königsrainer, Oliver Kohlbacher, Lothar Kanz, Alfred Königsrainer, Hans-Georg Rammensee, Stefan Stevanović and Sebastian P. Haen
Mapping the HLA ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation
AbstractImmune cell infiltrates have proven highly relevant for colorectal carcinoma (CRC) prognosis, making CRC a promising candidate for immunotherapy. Since tumors interact with the immune system via HLA-presented peptide ligands, exact knowledge of the peptidome constitution is fundamental for understanding this relationship. Here we comprehensively describe the naturally presented HLA-ligandome of CRC and corresponding non-malignant colon (NMC) tissue.
Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices
Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices Moreno Di Marco, Heiko Schuster, Linus Backert, Michael Ghosh, Hans-Georg Rammensee, Stefan Stevanovi? The Journal of Immunology October 15, 2017, 199 (8) 2639-2651; DOI: 10.4049/jimmunol.1700938
Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices
Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices Moreno Di Marco, Heiko Schuster, Linus Backert, Michael Ghosh, Hans-Georg Rammensee, Stefan Stevanovi? The Journal of Immunology September 13, 2017, ji1700938; DOI: 10.4049/jimmunol.1700938
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