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Articles by Linus Butt
Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease
Abstract Proteinuric kidney disease substantially affects renal tubules through incompletely understood mechanisms. We identify elongation of primary cilia in distal renal tubules in the context of glomerular nephropathy. In renal biopsies and mouse models, tubular injury correlates with ciliary elongation, tubule dilation, and disruption of the cortical actin cytoskeleton.
Mechanical forces at the kidney filtration barrier govern spatial orientation of podocyte processes on capillaries
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Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease
Significance Statement Podocin R229Q results from the most frequent missense variant in NPHS2, and its association with FSGS when podocin R229Q is transassociated with a second mutation in NPHS2 is well recognized. However, because results from observational studies are ambiguous and appropriate animal studies are lacking, its isolated pathogenic potency is not entirely clear.
Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease
Basic Research You have accessRestricted Access Linus Butt, David Unnersjö-Jess, Martin Höhne, Robert Hahnfeldt, Dervla Reilly, Markus M. Rinschen, Ingo Plagmann, Paul Diefenhardt, Sebastian Brähler, Paul T. Brinkkötter, Hjalmar Brismar, Hans Blom, Bernhard Schermer and Thomas Benzing JASN December 2021, ASN.2020060858; DOI: https://doi.org/10.1681/ASN.2020060858 This article requires a subscription to view the full text.
Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease
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An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes
Citation: Tröder SE, Ebert LK, Butt L, Assenmacher S, Schermer B, Zevnik B (2018) An optimized electroporation approach for efficient CRISPR/Cas9 genome editing in murine zygotes. PLoS ONE 13(5): e0196891. https://doi.org/10.1371/journal.pone.0196891 Copyright: © 2018 Tröder et al.
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