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Articles by Linwei Yang
De Novo Discovery of Bioactive Cyclic Peptides via Cellular Selection of Genetically Encoded Libraries
1 Introduction Cyclic peptides (CPs) represent a versatile class of molecular scaffolds for drug discovery due to their modular and genetically encodable composition, which enables the generation of highly diverse libraries through synthetic and molecular biology methods (or a combination of both) [1-4]. Display-based platforms, such as phage and mRNA display, have facilitated the de novo identification of CP lead compounds from large, genetically encoded libraries [5, 6].
Postoperative radiotherapy-induced pulmonary leiomyosarcoma in breast cancer: a case report and literature review
Abstract Radiation-induced sarcoma (RIS) is a rare and severe complication of radiotherapy following breast cancer surgery. It is characterized by a long latency period, high malignancy, limited clinical experience in diagnosis and treatment, and substantial individual variation in prognosis. This study reports a case of radiation-related pulmonary leiomyosarcoma that developed more than 20 years after radiotherapy for breast cancer.
Rapid discovery of cyclic peptide protein aggregation inhibitors by continuous selection - Nature Chemical Biology
Abstract Protein aggregates are associated with numerous diseases. Here we report a platform for the rapid phenotypic selection of protein aggregation inhibitors from genetically encoded cyclic peptide libraries in Escherichia coli based on phage-assisted continuous evolution (PACE). We developed a new PACE-compatible selection for protein aggregation inhibition and used it to identify cyclic peptides that suppress amyloid-β42 and human islet amyloid polypeptide aggregation.
Decoding the Ferroptosis-related Gene Signatures and Immune Infiltrati
Back to Journals » Journal of Inflammation Research » Volume 17 Authors Zhang B, Guo B, Kong H, Yang L, Yan H, Liu J, Zhou Y, An R, Wang F Received 30 September 2024 Accepted for publication 27 November 2024 Published 4 December 2024 Volume 2024:17 Pages 10333—10346 DOI https://doi.org/10.2147/JIR.S498740 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Tara Strutt Beilei Zhang,1,* Bin Guo,1,* Hancun...
Recent Research Advances on the Hippo‐Yki Pathway of Crustaceans: Current Knowledge and Potential Applications in Crustacean Aquaculture
References 1 and , “Hippo Signaling: Growth Control and Beyond,” Development 138 (2011): 9–22. 2, , , et al., “The Phenotype of Human STK4 Deficiency,” Blood 119 (2012): 3450–3457. 3, , , et al., “Tachykinin-Expressing Neurons Control Male-Specific Aggressive Arousal in Drosophila,” Cell 156 (2014): 221–235. 4, , , et al., “Hippo, Drosophila MST, Is a Novel Modifier of Motor Neuron Degeneration Induced by Knockdown of Caz, Drosophila FUS,” Experimental Cell Research 371 (2018): 311–321.
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