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Abstract PLK4 is a master regulator of centriole biogenesis. Knockdown or complete inhibition of PLK4 results in centrosome depletion. Recently, it was demonstrated that normal cells can tolerate centriole depletion by utilizing acentriolar condensates of pericentriolar material to function as microtubule organizing centers during mitosis.
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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
