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Lisa M. Connor

As seen in: Nature
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Articles by Lisa M. Connor

Preparation quality and epitranscriptomic modification influence circular RNA vaccine performance

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By Abby Martin, Kaitlin H. Buick, Thomas Bird, Joanna Kuang, Olga Palmer, Lydia White, Sarah Draper, Amy Foster, Gavin F. Painter, Isabelle Montgomerie, Wayne Patrick, Lisa M. Connor, Jessica F. Cotterell, Ngarangi C. Mason, Tifany Oulavallickal
| Nature Verified
Abstract Circular RNA (circRNA) is an emerging vaccine modality that is proposed to improve stability, reduce reactogenicity and extend antigen expression compared with linear mRNA. However, the relative contributions to vaccine performance of its covalently closed structure, its preparation quality and nucleotide modifications remain poorly described. Here, we systematically dissected these parameters in vivo across two antigen systems.
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Activation-Induced TIM-4 Expression Identifies Differential Responsiveness of Intestinal CD103+ CD11b+ Dendritic Cells to a Mucosal Adjuvant

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By Kerry L. Hilligan, Lisa M. Connor
| PLOS
Macrophage and dendritic cell (DC) populations residing in the intestinal lamina propria (LP) are highly heterogeneous and have disparate yet collaborative roles in the promotion of adaptive immune responses towards intestinal antigen. Under steady-state conditions, macrophages are efficient at acquiring antigen but are non-migratory. In comparison, intestinal DC are inefficient at antigen uptake but migrate to the mesenteric lymph nodes (mLN) where they present antigen to T cells.
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