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Articles by Liting Lu
The Hcp2b protein of APEC induces defective autophagy in HD11 cells by causing lysosomal dysfunction
ABSTRACT The type VI secretion system (T6SS) of avian pathogenic Escherichia coli (APEC) directly contributes to bacterial pathogenesis through the secretion of effector proteins. The haemolysin co-regulated protein (Hcp) serves as both a key effector and a structural component of the T6SS. Autophagy is a critical host defence mechanism for eliminating intracellular pathogens, but many bacteria exploit effector proteins to subvert this process.
Distinct Germline Mutation Landscape and Clinical Implications in Chinese Colorectal Cancer: A Large-Scale Genomic Analysis of 1094 Patients
1 Introduction Colorectal cancer (CRC) maintains its position as the third most prevalent cancer worldwide and the second leading cause of cancer-related mortality [1]. While traditionally predominant in developed nations, CRC incidence has shown a concerning upward trend in developing countries, particularly among younger demographics [2, 3].
Education and the politics of interruption: does the right always win?
Advanced search Educational Review Latest Articles Submit an article Journal homepage Full Article Figures & data Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/00131911.2026.2649715?needAccess=true "Education and the politics of interruption: does the right always win?." Educational Review, ahead-of-print(ahead-of-print), pp.
Teachers’ emotional experiences: towards a new emotional discourse
Advanced search Educational Review Latest Articles Submit an article Journal homepage Full Article Figures & data Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/00131911.2025.2595859?needAccess=true "Teachers’ emotional experiences: towards a new emotional discourse." Educational Review, ahead-of-print(ahead-of-print), p.
Multilevel pedagogical leadership in higher education: a non-affirmative approach
Advanced search Asia Pacific Journal of Education Latest Articles Submit an article Journal homepage Full Article Figures & data References Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/02188791.2025.2496046?needAccess=true Click to increase image sizeClick to decrease image size Additional information Funding This study was supported by The Hubei Provincial Teaching and Research Project [Award Number: 2024180] and The Teaching Reform Project of Huazhong...
PDE4DIP contributes to colorectal cancer growth and chemoresistance through modulation of the NF1/RAS signaling axis - Cell Death & Disease
Abstract Phosphodiesterase 4D interacting protein (PDE4DIP) is a centrosome/Golgi protein associated with cyclic nucleotide phosphodiesterases. PDE4DIP is commonly mutated in human cancers, and its alteration in mice leads to a predisposition to intestinal cancer. However, the biological function of PDE4DIP in human cancer remains obscure. Here, we report for the first time the oncogenic role of PDE4DIP in colorectal cancer (CRC) growth and adaptive MEK inhibitor (MEKi) resistance.
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