BBB blood–brain barrier CI confidence interval CNS central nervous system GWAS genome-wide association study ICH intracerebral hemorrhage IV instrumental variable IVW inverse-variance weighted MR Mendelian randomization OR odds ratio SNP single nucleotide polymorphism 1 Introduction Intracerebral hemorrhage (ICH), often referred to as hemorrhagic stroke, is a condition distinguished by the spontaneous bleeding within the brain parenchyma, typically resulting from ruptured blood vessels.
