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Abstract Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory follicular disease characterized by painful nodules, abscesses, and sinus tract formation that typically affects intertriginous areas, such as the axillae, inguinal regions, and gluteal region. This condition is often persistent and is difficult to control in clinical practice. In recent years, traditional Chinese medicine has been explored as a potential adjunct in its management.
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Abstract The Kondo effect offers an important paradigm to understand strongly correlated many-body physics. Although under intensive study, some of the important properties of the Kondo effect, in systems where both itinerant coupling and localized coupling play significant roles, are still elusive.
We first examined the role of GDF11 in bone remodelling by administering young adult mice (9 week old) with daily intraperitoneal injections of rGDF11 (0.1 or 0.3 mg kg−1 body weight; #120-11, PeproTech, Rocky Hill, NJ) or vehicle (saline) for 6 weeks. MicroCT analysis of the secondary spongiosa of the distal femur metaphysis revealed that the trabecular bone volume (BV/TV) in mice treated with the higher dose of rGDF11 (0.3 mg kg−1) was significantly lower than in mice treated with vehicle (Fig.
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