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Abstract Hantaviruses are rodent-borne pathogens that cause severe human disease for which no approved therapeutics are available. New World hantaviruses, including Andes virus (ANDV), use the cell-surface receptor protocadherin-1 (PCDH1) to enter host cells1. However, the structural basis of this interaction remains unclear. Here we describe the structure of PCDH1 bound to the ANDV spike at near-atomic resolution.
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