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Articles by L'Oreal Research
Changes in emotional response towards different facial application gestures following skincare application: An electroencephalogram approach
CONFLICT OF INTEREST STATEMENT SY, DV, DL, and FF are employees of L'Oréal group. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description ics70086-sup-0001-FigureS1.docxWord 2007 document , 236.5 KB Figure S1. REFERENCES 1, , , , , . World happiness report 2022. Well Being International.
Defining and decoding skin glow of women with skin phototype IV+ living in South Africa: Part 1
INTRODUCTION There is a great demand for healthy skin that is radiant without imperfections, and ‘glowing’ skin has become a significant trend with a demand that has gained momentum worldwide [1-3]. Glowing skin is now a significant consumer benefit to skincare, a trend evidenced by the increase in claims communication around glow between 2017 (13%) and 2021 (25%) [3] and continues to trend to date.
A New Hybrid Approach to Leverage Sensory Panel Data: How Can Expert Knowledge Add Value to Preference Mapping?
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. References 1995. Scale di misura e indicatori sociali. Cacucci. , , and . 2010. Sensory Evaluation in Food Processing. Springer Science & Business Media. , , and . 2003.
Differentiating solar lentigines from post‐inflammatory hyperpigmentation with hyperspectral imaging: A pilot study
CONFLICT OF INTEREST STATEMENT All authors are employees and/or shareholders of L'Oréal. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. REFERENCES 1, , . Clinico-epidemiological study and quality of life assessment in Melasma. Indian J Dermatol. 2015; 60(5): 519. 2, , , , , , et al.
Extracellular vesicles modulate skin aging biomarkers in a 3D reconstructed full-thickness skin model
Abstract Extracellular vesicles (EVs) are lipid-enveloped nanovesicles rich in microRNAs, proteins and lipids, that serve as potent mediators of intercellular communication. While EVs have demonstrated pro-regenerative potential in 2D and preclinical models, their impact on skin regeneration and aging processes in 3D reconstructed skin models has remained less explored.
An investigation of the sound of foam and its potential influence on the shampoo experience
CONFLICT OF INTEREST STATEMENT The study was funded by L'Oréal Research and Innovation in collaboration with the Yangtze River Delta Innovation Center, Zhejiang University. The Yangtze River Delta Innovation Center received a grant for this specific collaboration. DATA AVAILABILITY STATEMENT Research data are not shared. Supporting Information Filename Description ics70075-sup-0001-Supinfo.docxWord 2007 document , 65.6 KB Table S1. REFERENCES 1.
Lifespan, Healthspan, and the Expanding Role of Cosmetic Dermatology in Longevity Science
To the Editor, The growing distinction between lifespan, the total years lived, and healthspan, the years lived in good health, free from chronic disease and functional decline, has reshaped the priorities of longevity science. Within this evolving paradigm, cosmetic dermatology is emerging as more than a discipline of aesthetic refinement; it is becoming a meaningful participant in promoting healthspan and contributing to broader longevity strategies [1].
In Vitro Bioactivity of a Recombinant Human Collagen Peptide in a Filler Biomimetic Skin Model
1 Introduction Collagen, a critical component of the extracellular matrix (ECM), encompasses diverse subtypes and intricate supramolecular fibrillar arrangements, contributing significantly to the mechanical and functional properties of tissues such as skeleton, cartilage, bone, tendon, and skin [1].
Clinical Parameters Involved in Skin Tone Perception of Asian Population
1 Introduction Skin as the largest and most visible organ of the human body, plays an important role in beauty appearance. Although the preference for aesthetics could be different with multiple social and cultural factors, it is known that the facial skin status of an individual plays an important role in self-recognition and social interactions.
A New Method for Skin Color Classification Based on Global CIELAB Data and k‐Mean Clustering
1 Introduction Human skin color, a complex interplay of genetics, environment, and physiology, presents a captivating spectrum of diversity across the globe [1]. Its significance transcends mere aesthetics, profoundly influencing social interactions, cultural perceptions, and even health outcomes. In dermatology, skin color serves as a vital indicator of health, aiding dermatologists in diagnosing and monitoring skin conditions such as vitiligo, melasma, and skin cancer [2].
A New Method for Skin Color Classification Based on Global CIELAB Data and k ‐Mean Clustering
1 Introduction Human skin color, a complex interplay of genetics, environment, and physiology, presents a captivating spectrum of diversity across the globe [1]. Its significance transcends mere aesthetics, profoundly influencing social interactions, cultural perceptions, and even health outcomes. In dermatology, skin color serves as a vital indicator of health, aiding dermatologists in diagnosing and monitoring skin conditions such as vitiligo, melasma, and skin cancer [2].
Standardized In Vivo Method Using High‐Resolution Diffuse Reflectance Spectroscopy for Evaluating Sunscreen Effectiveness Against Ultraviolet A and High‐Energy Visible Light - Touti - 2025 - Photodermatology, Photoimmunology & Photomedicine - Wiley Online
1 Introduction Sunscreens are an essential component of a multifaceted approach to photoprotection, along with protective clothing and seeking shade. Wavelength ranges on the solar radiation spectrum that are relevant for their impact on skin are ultraviolet (UV), visible light (VL), especially high-energy blue-violet visible light (HEV), and infrared A (IRA) (Figure 1).
Advances in Longevity: The Intersection of Regenerative Medicine and Cosmetic Dermatology
1 Introduction Longevity, once a futuristic ideal, has become a clinical reality at the intersection of regenerative medicine and cosmetic dermatology [1-3]. Aging is now increasingly regarded as a modifiable process, shaped by genetic predisposition, lifestyle factors, and molecular pathways. Over the past 15 years, advancements in stem cell therapy, mitochondrial research, epigenetic reprogramming, and artificial intelligence (AI) have redefined the dermatologic approach to skin aging [4, 5].
Application of Antioxidant Mixture Prevents Cutaneous “Oxinflammaging” in Subjects Exposed to Particulate Matter
1 Introduction Environmental pollutants are major factors involved in the development of premature skin aging [1].
Understanding the water consumption associated with the use of hair care products: The impact of six hair characteristics on rinsing shampoos and conditioners
INTRODUCTION Most development research on shampoos and conditioners focuses on their physical properties and their performance in relation to cleanliness and user experience, and more recently, the environmental impacts of the production of the product. Life cycle analysis studies on shampoos are common, and the impact of the use phase has been clearly demonstrated.
Evaluation of the effect of an extract of Sphingomonas xenophaga present in a Thermal Spring Water in the management of sensitive skin associated with cutaneous vascular disorder
INTRODUCTION Rosacea is a chronic inflammatory skin disease where vascular abnormalities are frequent and can manifest as permanent redness, associated or not with hot flushes. The erythema associated with rosacea in particular represents a complex clinical challenge and likely has a multifactorial aetiology. Contributing factors include neurovascular dysregulation, increased levels of pro-inflammatory mediators and aberrant vasodilation.
Recombinant Type III Humanized Collagen Solution for Injection Promotes Skin Repair in Chinese Population: A Case Series
1 Introduction Facial erythema, characterized by redness and warmth, is a common outcome of skin injury. It can result from internal factors such as immunological responses [1, 2] or external causes like photodamage [3, 4]. Erythema, particularly from ultraviolet (UV) exposure, is a prominent sign of skin damage, often associated with inflammation, warmth, and tenderness [3, 4].
An Automatic AI‐Based Algorithm That Grades the Scalp Surface Exfoliating Process From Video Imaging. Application to Dandruff Severity and Its Validation on Subjects of Different Ages and Ethnicities
1 Introduction In its normal status, the adult human scalp surface (≈600 cm2) is a terra incognita, visually speaking, hidden by the presence of some 100 000–130 000 hair of various diameters (70–120 μm) emerging from their respective pilo-sebaceous duct that additionally drains the sebum excretion. although, hardly visible to the eyes, the scalp is nevertheless a site where itch is frequently presented [1, 2].
Unlocking Longevity in Aesthetic Dermatology: Epigenetics, Aging, and Personalized Care
1 Introduction For decades, the prevailing belief was that our genetic code primarily dictated aging. The assumption that genes were the primary determinant of how we age, including the visible signs of aging, shaped much of the approach within aesthetic dermatology [1].
In vivo efficacy of a stabilized Vitamin C‐based serum at pH 6 on some ageing facial signs of women of different ages and phototypes
CONFLICT OF INTEREST STATEMENT All authors are employees of the L'Oréal Research & Innovation Dept. REFERENCES 1. Photodamage of the skin: protection and reversal with topical antioxidants. J Cosmet Dermatol. 2004; 3: 149–155. 2, , . In vitro antioxidant activity and In vivo efficacy of topical formulations containing vitamin C and its derivatives studied by non-invasive methods. Skin Res Technol. 2008; 14(3): 376–380. 3, . Topical vitamin C in aging. Clin Dermatol. 1996; 14(2): 227–234. 4, .
Reinforcing chemically treated human hair with citric acid
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1. Chemical and physical behavior of human hair. 4th ed. New York: Springer-Verlag; 2002. 2, , , . Analysis of hair lipids and tensile properties as a function of distance from scalp. Int J Cosmet Sci. 2005; 27: 193–197. 3, , , , , , et al. Improving the mechanical properties of damaged hair using low-molecular weight hyaluronate. Molecules. 2022; 27(22): 7701. 4, , , , .
Revealing the Therapeutic Potential: Investigating the Impact of a Novel Witch Hazel Formula on Anti‐Inflammation and Antioxidation
1 Introduction Witch hazel (Hamamelis virginiana) is a natural plant extract known for its medicinal properties for centuries. Obtained from the leaves and bark of the North American witch hazel shrub, this extract contains a complex mixture of bioactive compounds that contribute to its multifaceted benefits [1]. Tannins, the primary constituents of witch hazel extract, account for its remarkable astringent properties [2].
Grading facial aging: Comparing the clinical assessments made by three dermatologists with those obtained by an AI‐based scoring system that analyses selfie pictures. A focus on Chinese subjects of both genders - Wang - International Journal of Cosmetic S
CONFLICT OF INTEREST STATEMENT WW, FF, HW, CY, RJ and JH are employees of L’Oréal group. Supporting Information Filename Description ics13016-sup-0001-Tables.docxWord 2007 document , 18.7 KB Table S1. Table S2. REFERENCES 1. Clinical and histological features of intrinsic versus extrinsic skin aging. In: BA Gilchrest, J Krutmann, editors. Skin aging. Berlin Heidelberg: Springer-Verlag; 2006. p. 9–22. 2, , , . Intrinsic and extrinsic factors in skin ageing: a review. Int J Cosmet Sci. 2008; 30(2): 87–95.
The dimer effect: A refinement approach towards skin sensitization assessment in‐chemico using Amino acid Derivative Reactivity Assay
CONFLICT OF INTEREST STATEMENT The authors did not report any conflict of interest. REFERENCES , , , , & (2023). Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization. ALTEX, 40, 606–618. https://doi.org/10.14573/altex.2212201 , , & (2014). Chemical sensitization. In J. Kleinjans (Ed.), Toxicogenomics-based cellular models (pp. 67–87). Elsevier Inc. Academic Press. , , , , , , , , , & (2006).
Development of a defined approach for eye hazard identification of solid chemicals according to the three UN GHS categories
Main Article Content Abstract Article Details Alépée, N. and Adriaens, E. (2024) “Development of a defined approach for eye hazard identification of solid chemicals according to the three UN GHS categories”, ALTEX - Alternatives to animal experimentation. doi: 10.14573/altex.2401191. Articles Adriaens, E., Verstraelen, S., Desprez, B. et al. (2021).
Our Beauty Born from Science
Our R&I model: scientifically and responsibly invented "L'Oréal was born from science, from a vision, created from the idea of a chemist. Since then, science has remained at the heart of our model. And it is without a doubt, the performance, safety and superior quality of our products that have been the foundation of our success for over 110 years.
2‐Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity
Research of new ingredients that can prevent excessive melanin production in the skin is an important but challenging task due to multi-parameter considerations. An innovative methodology is described, based notably on high-throughput screening test, in silico method predicting physico-chemical properties, environmental parameters, and physiologic pigmented biological models, which led to the discovery of 2-mercaptonicotinoyl glycine.
A Bayesian network meta‐analysis of 14 molecules inhibiting UV daylight‐induced pigmentation
Hyperpigmentation disorders are very frequent, affect the quality of life and may become a psychological burden for afflicted patients. Many anti-pigmenting or depigmenting agents are available with various efficacy and almost no comparative data. 2-mercaptonicotinoyl glycine (2-MNG) was recently proposed as a viable candidate showing safe and effective results on hyperpigmentation control in vitro and in vivo.
2‐Mercaptonicotinoyl glycine prevents UV‐induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study
2-MNG 2-mercaptonicotinoyl glycine 4-n-BR 4-n-butyl-resorcinol DT delayed tanning IPD immediate pigment darkening ITA individual typology angles LHA lipohydroxy acid MED minimal erythemal dose MSX Mexoryl-SX PPD persistent pigment darkening UVA ultraviolet A UVB ultraviolet B UVDL UV daylight UVR ultraviolet rays 1 INTRODUCTION Ultraviolet rays (UVR) impact skin pigmentation via two successive reactions with distinct mechanisms.1 First, photooxidation and redistribution of preexisting melanin...
Support for dermatological research in Sub‐Saharan Africa: insights from African hair and skin research programs
Introduction People of African ancestry have specific physical characteristics, such as highly pigmented skin and curly or afro-textured hair that differ from other ethnic categories and thus require tailored care.
Poroelastic behavior and water permeability of human skin at the nanoscale
Skin is a complex biological organ involved, among others, in processes associated with wound healing, skin hydration, and the regulation of body temperature. The surface area of the skin, which constitutes the largest tissue in our body, is estimated to be approximately 1.6 m2 (1) and is the body's first line of defense against microbes and harmful environments.
Skin microbiome dysbiosis and the role of Staphylococcus aureus in atopic dermatitis in adults and children: A narrative review
Abstract A dysfunctional epidermal barrier, which may be associated with mutations in the filaggrin gene in genetically predisposed individuals or harmful effects of environmental agents and allergens, contributes to the development of atopic dermatitis (AD) due to an interplay between the epithelial barrier, immune defence and the cutaneous microbiome.
Non‐destructive, reverse iontophoretic extraction of phytochemicals from Mangifera indica, Centella asiatica, Punica granatum, and Citrus sinensis
Abstract For the commercial-scale isolation of phytochemicals, a suitable plant biomass source (including species, origin, growing season, etc.) must be identified, and frequent analytical verification is required to ensure that the phytochemicals are present at predefined minimum threshold concentrations. While the latter are typically assessed in the laboratory, a more efficient and less resource-intensive approach would involve non-destructive and environmentally friendly measurements in situ.
Extraction of phytochemicals from the pomegranate (Punica granatum L., Punicaceae) by reverse iontophoresis
Extraction of phytochemicals from the pomegranate (Punica granatum L., Punicaceae) by reverse iontophoresis† Kieran Moore, a Shaun B. Reeksting, b Vimal Nair,c Steve T. Pannakal,c Nita Roy,c Joan Eilstein,c Sébastien Grégoire,d M. Begoña Delgado-Charro*a and Richard H. Guy a Abstract Plant metabolic profiling can provide a wealth of information regarding the biochemical status of the organism, but sample acquisition typically requires an invasive and/or destructive extraction process.
A Psychosocial Exploration of Augmented Reality and Virtual Reality Apps in Cosmetic Procedures
1 Introduction Doctor–patient relationships have undergone a profound transformation in modern health care. Digital platforms provide patients unprecedented access to health information, empowering them as active participants in their care. This marks a significant departure from the traditional doctor-centered approach, evolving into cooperative treatment planning [1, 2].
Mapping the efficacy and mode of action of ethylzingerone [4-(3-ethoxy-4-hydroxyphenyl) butan-2-one] as an active agent against Burkholderia bacteria.
Environmental Microbiology Laura Rushton, Ahmad Khodr, Florence Menard-Szczebara, Jean-Yves Maillard, Sylvie Cupferman, Eshwar Mahenthiralingam DOI: 10.1128/AEM.01808-20 ABSTRACT Burkholderia cepacia complex (Bcc) bacteria are intrinsically antimicrobial resistant opportunistic pathogens and key risk species in the contamination of non-food industrial products.
Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol
Abstract OECD test guideline 428 compliant protocol using human skin was used to test the penetration of 56 cosmetic‐relevant chemicals. The penetration of finite doses (10 μL/cm2) of chemicals was measured over 24 hours. The dermal delivery (DD) (amount in the epidermis, dermis and receptor fluid [RF]) ranged between 0.03 ± 0.02 and 72.61 ± 8.89 μg/cm2. The DD of seven chemicals was comparable with in vivo values.
Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum
Partition (K) and diffusion (D) coefficients are important to measure for the modelling of skin penetration of chemicals through the stratum corneum (SC). We compared the feasibility of three protocols for the testing of 50 chemicals in our main studies, using three cosmetics-relevant model chemicals with a wide range of logP values.
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