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Introduction Click to copy section linkSection link copied! The dopamine D2 receptor (D2R) is a member of the G protein–coupled receptor (GPCR) family and transduces signals primarily through the coupling and activation of heterotrimeric Gαβγ proteins (Gi/O type) and β-arrestins.
Abstract Dopamine D2 receptor (D2R) regulates key aspects of motor control, cognition, and reward. Its function depends not only on ligand binding and signaling efficacy, but also on the dynamic control of receptor localization at the cell surface. Neuronal Calcium Sensor 1 (NCS−1) is a calcium binding protein which directly interacts with D2R in a Ca2+-dependent manner. Here, we investigated the regulatory role of NCS−1 in D2R localization and function.
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