ALL acute lymphoblastic leukemia AML acute myeloid leukemia AML-MRC AML with myelodysplastic changes AYA adolescents and young adults BNP B-type natriuretic peptide CNS central nervous system COG Children's Oncology Group CR complete response CRi complete response with incomplete neutrophil recovery CRp complete response with incomplete platelet recovery CTCAE Common Terminology Criteria for Adverse Events DL dose level DLT dose limiting toxicity EFS event-free survival FDA Food and Drug...