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1 Introduction Heterocycles remain a central class of privileged molecular architectures, with nitrogen-containing rings featuring in ≥59% of FDA-approved small molecule drugs [1-4]. Among these, aminopyrazoles represent a versatile heteroaromatic motif frequently encountered in medicinal chemistry and drug discovery [5], featuring in therapeutics for parasitic diseases [6-10], cancer [11-15], viral infections [16-18], and many others (Figure 1A) [19-23].
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