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Merging alkenyl C−H activation with ring-opening of 1,2-oxazetidines: ruthenium-catalyzed aminomethylation of enamides 1,2-Oxazetidines have been utilized as formaldimine precursors for direct aminomethylation of enamides under a Ru(II) species. By merging alkenyl C−H activation with ring-opening of 1,2-oxazetidines, this efficient protocol provides a facile and novel approach to synthesize Z-selective aminomethyl substituted enamides.
Ruthenium-catalyzed C–H functionalization of enamides with isocyanates: easy entry to pyrimidin-4-ones Ruthenium-catalyzed heteroannulation between enamides and isocyanates has been realized as a complementary approach to the conventional strategies for pyrimidin-4-ones synthesis. High step- and atom-economy was achieved for the rapid construction of such privileged scaffolds found in a multitude of pharmaceutical compounds.
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