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Abstract In the Toll-like receptor (TLR) signal transduction pathways, activated receptors are present for mere minutes within the initial, membrane-proximal signalling complexes called proto-myddosomes1. Proto-myddosomes are rapidly released from TLRs to self-assemble (that is, mature) into enzyme-rich, cytosolic supramolecular organizing centres called myddosomes2,3,4. Myddosomes induce hours-long inflammatory gene expression5,6,7,8,9,10.
Publication Date 2024-08-11 First Faculty Advisor Samuel Payne First Faculty Reader Matthew Bailey Honors Coordinator Steven Peck Keywords tumor suppressor, RB1 mutation, glioblastoma multiforme, CPTAC, TP53, tumor-infiltrating lymphocytes Abstract Glioblastoma Multiforme (GBM) is an incredibly invasive and particularly lethal central nervous system cancer. Recent work has shown that GBM patients with mutated RB1 have greater overall survival.
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