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Lucie Rospape

As seen in: Nature
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Articles by Lucie Rospape

Chemokine and opioid peptide scavenging through constitutive and ligand-induced release of ACKR3-bearing extracellular vesicles

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By Christie B. Palmer, Max Meyrath, Caitrin Crudden, Manuel Counson, Anne-Katrin Rohlfing, Lotte Di Niro, Ana Alonso Bartolomé, Cláudio Pinheiro, Vanessa Klapp, Stéphane Laporte Verified, Stephen Hill, Julia Drube, Carsten Hoffmann, Rob Leurs, Michel Bouvier, Meinrad Gawaz, An Hendrix, Etienne Moussay, Martine J. Smit, Jerome Paggetti, Martyna Szpakowska, Andy Chevigne, Lucie Rospape, Ester Cassano
| Nature Verified
Abstract Atypical chemokine receptors (ACKRs) are non-signaling GPCRs that regulate ligand availability, with ACKR3 functioning as a dual scavenger of chemokines and opioid peptides. Here, we demonstrate that following ligand stimulation, besides the canonical internalization, ACKR3 is released on extracellular vesicles (EVs). ACKR3 was also found on EVs released under basal conditions, although to a lesser extent.
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