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Abstract Obesity is a major public health concern frequently associated with an increased susceptibility to neuropsychiatric symptoms, highlighting the need to elucidate the pathophysiological mechanisms underlying this comorbidity.
Take CME Quiz Information Copyright 2025, SLACK Incorporated Address correspondence to Kuan-Pin Su, MD, PhD, Department of Psychiatry, China Medical University Hospital, No. 2 Yuh-Der Road, Taichung 404, Taiwan; email: cobolsu@gmail.com.
Context Inflammatory cytokines or cytokine inducers can alter basal ganglia activity, including reducing responsiveness to rewarding stimuli that may be mediated by cytokine effects on dopamine function. Objectives To determine whether long-term administration of the inflammatory cytokine interferon alfa reduces the basal ganglia response to reward and whether such changes are associated with decreased presynaptic striatal dopamine function and altered behavior.
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