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Articles by Lukas Kahlert
Synthesis of functionalized 2,3-diaminopropionates and their potential for directed monobactam biosynthesis
Synthesis of functionalized 2,3-diaminopropionates and their potential for directed monobactam biosynthesis† Michael S. Lichstrahl, ‡a Lukas Kahlert, ‡a Rongfeng Li, ‡a Trevor A. Zandi, bcd Jerry Yanga and Craig. A. Townsend *a Abstract The N-sulfonated monobactams harbor considerable potential to combat emerging bacterial infections that are problematic to treat due to their metallo-β-lactamase mediated resistance against conventional β-lactam antibiotics.
Biosynthesis of 6‐Hydroxymellein Requires a Collaborating Polyketide Synthase‐like Enzyme
Abstract The polyketide synthase (PKS)‐like protein TerB, consisting of inactive dehydratase, inactive C‐methyltransferase, and functional ketoreductase domains collaborates with the iterative non reducing PKS TerA to produce 6‐hydroxymellein, a key pathway intermediate during the biosynthesis of various fungal natural products.
The Same but Different: Multiple Functions of the Fungal Flavin Dependent Monooxygenase SorD from Penicillium chrysogenum
The Same but Different: Multiple Functions of the Fungal Flavin Dependent Monooxygenase SorD from Penicillium chrysogenum Sorbicillinoids are a large family of fungal secondary metabolites with a diverse range of structures and numerous bioactivites, some of which have pharmaceutical potential.
Diels Alder Reactions During the Biosynthesis of Sorbicillinoids
Research Article Elizabeth Skellam Corresponding Author E-mail address: lizskellam@hotmail.co.uk E-mail address: elizabeth.skellam@oci.uni-hannover.de Leibniz Universitat Hannover, Institute for Organic Chemistry, Schneiderberg 1B, 30167 Hannover, GERMANY Search for more papers by this author PDF PDF Share Abstract The sorbicillinoids are a class of biologically active and structurally diverse fungal polyketides arising from sorbicillin.
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