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Lukun Yang

As seen in: Nature, Canadian Journal of Infectious Diseases & Medical Microbiology, Dove Medical Press
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Articles by Lukun Yang

Non-canonical role of Ku80 stabilizes Rab7A to enhance mitolysosome formation and chemotherapy in liver cancer

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By Baojia Zou, Lukun Yang, Yihua Dai, Peiping Li, Manyao Zhang, Jianzhong He, Decheng Li, En Lin, Chaonong Cai, Yiguang Lin, Mingjian Lu, Jian Li, Bailiang He
| Nature Verified
Abstract Targeting mitophagy is a potential strategy to tackle chemoresistance and improve chemotherapy in cancer. Ku80 is reported to play a role in chemoresistance and could exert non-canonical functions in mitophagy, but the mechanism remains largely unknown. Here, we report that increased expression of Ku80 leads to prominent mitophagy in liver cancer cells and tissues. Mechanistically, Ku80 directly regulates Rab7A to enhance formation of mitolysosomes.
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Higher Expression of Ku80 and Ku70 Indicated Hotter Tumor Immune Micro

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By Lukun Yang, Peiping Li, Jiafan Chen, Chaonong Cai
| Dove Medical Press
Lukun Yang,1,2,* Ling Li,3,* Peiping Li,1,* Jiafan Chen,1 Chaonong Cai,1 Yingbin Jia,1 Jian Li,1 Baojia Zou1 1Department of Hepatobiliary Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong Province, People’s Republic of China; 2Department of Anesthesiology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, People’s Republic of China; 3Department of Pharmacy, The Fifth Affiliated Hospital, Sun Yat-Sen University,...
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