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Abstract This study aimed to characterize behavioral alterations induced by chronic constriction injury (CCI) of the sciatic nerve and hippocampal ferroptosis in rats and to explore the association between hippocampal ferroptosis and behavioral changes accompanying neuropathic pain (NP). Ferrostatin-1 (10 mg/kg) and Erastin (10 mg/kg) were injected intraperitoneally into thirty-two male SD rats for two consecutive days.
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