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Abstract To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic variants contribute to gene expression, have been performed in heterogeneous brain tissues rather than specific cell types. In this study, we performed an eQTL analysis using single-nuclei RNA sequencing from 192 individuals in eight brain cell types derived from the prefrontal cortex, temporal cortex and white matter.
Introduction The nature and role of neuron–glia interactions in controlling the development, function, and pathology of our brains remain among the greatest unsolved mysteries in neurobiology today. In particular, the development and function of astrocytes, a cell type that constitutes approximately one-third of mouse brain cells and nearly half of human brain cells, remain essentially uncharacterized.
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