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A close temporal association has been observed between the onset of some autoimmune connective tissue diseases (CTD) and various cancers, suggesting that the appearance of a CTD may sometimes represent a paraneoplastic phenomenon. For example, adult patients with dermatomyositis (DM) with anti-transcription intermediary factor 1 (anti-TIF1) autoantibodies have a dramatically increased risk of developing cancer compared to the general population [1].
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