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Porphyrins are organic heterocyclic macrocycles with photophysical properties well-suited for clinical phototherapy and cancer imaging. However, their wider application in the clinical management of disease is barred by poor aqueous solubility, bioavailability, tumour accumulation and skin phototoxicity. These limitations instigated the development of supramolecular platforms that improved porphyrin pharmacokinetics and tumour-homing.
* Corresponding authors a Princess Margaret Cancer Centre, University Health Network, 101 College Street, Toronto, Canada E-mail: gzheng@uhnresearch.ca b Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Canada c Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, Canada
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