Artificial intelligence (AI) has become an increasingly prominent driver of clinical innovation, and men’s health is now beginning to feel its impact. In this context, the recent review by Clark and colleagues [1] provides a timely overview of how machine learning (ML), deep learning (DL), and natural language processing (NLP) are being explored in erectile dysfunction (ED), male infertility, Peyronie’s disease, testosterone deficiency, and premature ejaculation.