Background: Cetuximab in combination with platinum-based chemotherapy followed by cetuximab monotherapy until progression significantly prolonged overall survival (OS) in patients with recurrent and/or metastatic squamous-cell carcinoma of the head and neck (SCCHN) (EXTREME trial)1. SOCCER is a prospective, non-interventional study to evaluate symptom control in patients with recurrent and/or metastatic SCCHN treated with Cetuximab in combination with platinum-based chemotherapy or radiotherapy.